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Isaac Salazar-Ciudad

 

 


Ramón y Cajal Researcher

 

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I am senior researcher on the mechanisms of evolution. My focus is on morphological evolution and to this end I have been developing theories about the interdependence between the dynamics of development and the dynamics of evolution. This has brought me to study the mechanisms of pattern formation in development that are responsible for the generation of phenotypic variation in populations. Thus, my aim is to understand the multiple types of relationships between genetic (and environmental) variation and morphological variation in different animal species and their effects on evolution. In practice my work involves integrating experimental data in developmental biology into mathematical models of development and evolution.

 


  Download CV (July 2008)



Publicaciones

 

Publications:


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22. Salazar-Ciudad I, Jernvall J.

A computational model of teeth and the developmental origins of morphological variation.

Nature. 2010 Mar 25;464(7288):583-6.


21. Salazar-Ciudad I.

Morphological evolution and embryonic developmental diversity in metazoa.

Development. 2010 Feb;137(4):531-9.

20. Salazar-Ciudad,I.

Looking at the origin of phenotypic variation from pattern formation gene networks.
Journal of Biosciences. 2009 Oct;34(4):573-87.

19. Salazar-Ciudad,I.

Evolution in biological and non-biological systems under different mechanisms of generation and inheritance.

Theory in Biosciences Nov;127(4):343-58. 2008 download file


18. Isaac Salazar-Ciudad 

Making Evolutionary Predictions About the Structure of Development and Morphology:

Beyond the Neo-Darwinian and Constraints Paradigms
 

In: Minelli & Fusco - Evolving Pathways 2007 download pdf file


17. Isaac Salazar-Ciudad

Tooth Morphogenesis in vivo, in vitro, and in silico
Current Topics in Developmental Biology 2007. download pdf file


16. Isaac Salazar-Ciudad
    On the origins of morphological variation, canalization, robustness, and evolvability
    Integrative and Comparative Biology 2007. download pdf file.


15. Jukka Jernvall and Isaac Salazar-Ciudad
    The economy of tinkering mammalian teeth.
    Novartis Found Symp. 2007;284:207-16; discussion 216-24.


14. Reiner A. Veitia, Isaac Salazar-Ciudad.
    Commonalities in fly embryogenesis and mammalian pituitary patterning.
    Trends Endocrinol Metab. 2007 Sep;18(7):261-265.    


13. Elina Järvinen, Isaac Salazar-Ciudad, Walter Birchmeier, Makoto M. Taketo , Jukka Jernvall, and Irma Thesleff.
    Increased epithelial Beta-catenin unlocks renewal of mouse teeth.
    Proceedings of the National Academy of Sciences, USA. 2006 Dec 5;103(49):18627-32   


12. Isaac Salazar Ciudad.
    On the origins of morphological disparity and its diverse developmental bases.
    Bioessays. 2006 Nov;28(11):1112-22. download pdf file .  .  


11. Isaac Salazar Ciudad.
    Developmental constraints vs. variational properties: How Pattern formation can help to understand evolution and development.
    Journal of experimental zooloy: Part B: molecular development evolution. 2005       
    October. download pdf file.


10. Isaac Salazar Ciudad and Jukka Jernvall.
    Graduality and Innovation in the evolution of complex phenotypes: Insights from development.
    Journal of experimental zooloy: Part B: molecular development evolution. 2005. download pdf file


9. Isaac Salazar Ciudad and Jukka Jernvall
    How different types of pattern formation mechanisms affect the evolution of form and  
    development
    Evolution and development. Jan-Feb;(1):6-16 2004. download pdf file


8. Isaac Salazar Ciudad, Jukka Jernvall and Stuart Newman.
    Mechanisms of pattern formation in development and evolution.
    Development 2003 130: 2027-2037(2003).download pdf file


7. Isaac Salazar Ciudad and Jukka Jernvall.
    A gene network model accounting for development and evolution of mammalian teeth.
    Proceedings of the National Academy of Sciences USA. 99: 8116-8120. 2002 download pdf file


6. Isaac Salazar-Ciudad, Stuart A. Newman and Ricard V. Solé
    Phenotypic and dynamical transitions in model genetic networks I: Emergence of patterns and     genotype-phenotype relationships
    Evolution and Development.  Mar-Apr;3(2):84-94.(2001).download pdf file

    A  news and views about these two articles has appeared in Nature.
    Eörs Szathmáry, Nature (2001), 10 May.vol.111, 144-145


5. Isaac Salazar-Ciudad, Ricard V. Solé and Stuart A. Newman
    Phenotypic and dynamical transitions in model genetic networks II: Application to the
    evolution of segmentation mechanisms
    Evolution and Development, Mar-Apr;3(2):95-103.(2001).  download pdf file

    A  news and views about these two articles has appeared in Nature.
    Eörs Szathmáry, Nature (2001), 10 May.vol.111, 144-145


4.  Ricard V. Solé, Isaac Salazar-Ciudad and Stuart A. Newman
    Gene network dynamics and the evolution of development
    Trends in Ecology and Evolution 15, 479-480. (2000)


3.  Ricard V. Solé, Isaac Salazar-Ciudad and Jordi García-Fernandez
     Common Pattern Formation in a Gene Network Model of Morphogenesis
     Physical Review A


2.  Isaac Salazar-Ciudad, Jordi García-Fernandez and Ricard V. Solé
     Gene networks capable of pattern formation: from induction to reaction-diffusion
     Journal of Theoretical Biology 205, 587-603. (2000) download pdf file


1.  Ricard V. Solé, Isaac Salazar-Ciudad and Jordi García-Fernandez
     Landscapes, Gene Networks and Pattern Formation: on the Cambrian Explosion
     Advances in Complex Systems 2, 313-337  (1999) 


 
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